Enzymes

PH and enzyme activity

so as we took with the temperature being one of the factors that affect the lock and key mechanism

pH also affects it as , it denature the enzyme or changes the shape of the active site , so no or less enzyme substrate complex within the body

everye organism has a specific pH , lets take the bactria as ex

when it entre the body through the food and goes to the stomach they face the gastric juice which has a very low pH, so the enzymes of the Bactria start to denature killing the bacteria